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Zotepine
Zotepine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 5-hydroxytryptamine receptor 1B, sodium-dependent serotonin transporter, 5-hydroxytryptamine receptor 1E, D(4) dopamine receptor, sodium-dependent noradrenaline transporter, histamine H1 receptor, D(2) dopamine receptor, 5-hydroxytryptamine receptor 7, 5-hydroxytryptamine receptor 2C, alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1D, D(3) dopamine receptor, and 5-hydroxytryptamine receptor 6.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AX: Other antipsychotics in atc
— N05AX11: Zotepine
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DeliriumD003693R41.0———1—1
SchizophreniaD012559EFO_0000692F20———1—1
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.9————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameZOTEPINE
INNzotepine
Description
Zotepine is a dibenzothiepine and a tertiary amino compound. It has a role as an alpha-adrenergic drug, a serotonergic drug and a second generation antipsychotic.
Classification
Small molecule
Drug classtricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc21
Identifiers
PDB6A94
CAS-ID26615-21-4
RxCUI40003
ChEMBL IDCHEMBL285802
ChEBI ID32316
PubChem CID5736
DrugBankDB09225
UNII IDU29O83JAZW (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HTR1B
HTR1B
SLC6A4
SLC6A4
HTR1E
HTR1E
DRD4
DRD4
SLC6A2
SLC6A2
HRH1
HRH1
DRD2
DRD2
HTR7
HTR7
HTR2C
HTR2C
ADRA2B
ADRA2B
HTR1A
HTR1A
HTR2A
HTR2A
HTR1D
HTR1D
DRD3
DRD3
HTR6
HTR6
Organism
Homo sapiens
Gene name
HTR1B
Gene synonyms
HTR1DB
NCBI Gene ID
3351
Protein name
5-hydroxytryptamine receptor 1B
Protein synonyms
5-HT-1D-beta, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, S12, Serotonin 1D beta receptor, Serotonin receptor 1B
Uniprot ID
Q4VAY7
Mouse ortholog
Htr1b (15551)
5-hydroxytryptamine receptor 1B (P28334)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 668 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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250 adverse events reported
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